|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.
|
27923803 |
2017 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have measured deamination events in the human p53 gene, which contains a large percentage of C to T transitions in skin cancers.
|
9813119 |
1998 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate this methodology is a powerful tool to study phenotypic reversion of nucleotide excision repair-deficient cells such as cellular DNA repair properties and we suggest that it may be used to study other cellular parameters (cell cycle regulation, p53 stability or immunosurveillance-controlling factors) involved in UV-induced skin cancers and which reliability requires the use of untransformed cells.
|
8960128 |
1996 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that inhibition of the premalignant AK lesions as well as a reduction in the expression of p53 and in spermidine concentrations may serve as surrogate endpoint biomarkers of DFMO and possibly other topically administered skin cancer chemopreventive agents.
|
11801552 |
2002 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan.
|
12635827 |
2003 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
CTD_human |
We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan.
|
12635827 |
2003 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We assessed the association of the p53 codon 72 polymorphism with tanning response, and its interaction with MC1R variants on tanning response and skin cancer risk.
|
18510673 |
2008 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also found a significant association between p53-72R homozygosity and nonmelanoma skin cancer in renal transplant recipients (basal cell carcinoma, p < 0.01; squamous cell carcinoma, p < 0.05) but not in immunocompetent patients compared with skin type matched controls. p53 sequence data revealed mutations in 30 of 70 (42.9%) nonmelanoma skin cancers, 28 (93%) of which were in the p53-72R allele.
|
12164929 |
2002 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers.
|
11174390 |
2001 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
UV-related mutations of the p53 gene have been identified in human skin cancers.
|
8030743 |
1994 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
UV radiation has been shown to induce the expression of the p53 tumor suppressor gene, and is known to produce "signature" mutations in p53 in human and mouse skin cancers and in the tumor suppressor gene patched in human basal cell carcinoma.
|
9343491 |
1997 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using LMPCR (ligation-mediated polymerase chain reaction), we show that environmentally relevant UVB light induces CPD at CC and Pyr(m)C positions much more frequently than does UVC light, and that all eight skin cancer hot spots in p53 are also hot spots for UVB-induced CPD.
|
9383997 |
1997 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
USA, in press, 1993) report such a strand bias of p53 mutation in skin cancers from XP-C patients.
|
8221675 |
1993 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer.
|
9635858 |
1998 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To relate clinical observations to molecular events, the nature of p53 mutations found in skin cancers from psoriasis patients is also analyzed.
|
11702610 |
2002 |
|
Malignant neoplasm of skin
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
To ascertain whether perturbation of methylation plays a role in such carcinogenesis, the degree of methylation of p53 and p16 gene in DNA obtained from blood samples of people chronically exposed to arsenic and skin cancer subjects was studied.
|
16251483 |
2006 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study's data suggest that psoralen + ultraviolet A-induced p53 mutations may play an important part in the development of nonmelanoma skin cancer in psoralen + ultraviolet A-treated patients, but these mutations are likely to act in concert with the effects of other carcinogenic exposures, particularly ultraviolet B, in the development of skin cancer.
|
12190879 |
2002 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This hypothesis was confirmed by our finding that sunscreens used in p53 mutation inhibition experiments also protected mice against UVB-induced skin cancer.
|
18173701 |
2008 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This clonal expansion of mutant p53 may provide a molecular basis for high risk of developing subsequent new skin cancers in patients with BCC.
|
7769260 |
1995 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
These studies indicate that reconstituting p53 tumor suppressor functions in vivo by small molecular weight compounds may block the pathogenesis and progression of skin cancer.
|
18060030 |
2007 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These studies demonstrate that inactivation of the p53 tumor suppressor gene, as well as activation of ras oncogenes, may be involved in the pathogenesis of some human skin cancers.
|
1793482 |
1991 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that p53 mutations may be involved in the malignant conversion of AKs to SCCs and that p53 may be useful as a biomarker to study the potential modulatory effects of cancer chemopreventive agents against skin cancer.
|
7923098 |
1994 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results confirm the utility of PCR-based p53 gene mutation assays for the measurement of exposure to UV as well as for predicting the risk of UV-associated skin cancer.
|
9184777 |
1997 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings showed that p53 gene mutation rate in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan is high and that the mutation types are different from those in UV-induced skin cancers.
|
10362120 |
1999 |